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Collagen in tendon, ligament, and bone healing. A current review

Abstract: Cells that produce a particular type of collagen under normal physiologic circumstances can be induced by certain local triggers to change the amount and type of collagen synthesized. This has become most apparent during bone, tendon, and ligament healing, where cells that once produced the collagen of normal intact tissue are induced to synthesize […]

Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: A mechanistic exploration

Abstract: Arthritis afflicts approximately 43 million Americans or approximately 16.6% of the US population. The two most common and best known types of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA). A significant amount of scientific research has been done in attempts to explain what initiates forms of arthritis, how it is promoted and perpetuated […]

What Is Collagen? – Dr. Ananya Mandal, MD

Summary: Collagen is a protein found primarily in animals, which is made up of carbon, oxygen, and hydrogen, and contains specific amino acids. It makes up approximately 30% of the proteins in the body, and is found in bones, tendons, ligaments, skin, and other connective tissues. Its main purpose is to give strength and protection […]

Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial

Abstract Objective: The aim of this randomized controlled study was to evaluate the efficacy of oral native type II collagen treatment on the symptoms and biological markers of cartilage degradation, when given concomitantly with acetaminophen in patients with knee osteoarthritis. Materials and Methods: Thirty-nine patients diagnosed with knee osteoarthritis were included and randomly distributed into […]

Oral administration of type-II collagen peptide 250–270 suppresses specific cellular and humoral immune response in collagen-induced arthritis

Abstract Oral antigen is an attractive approach for the treatment of autoimmune and inflammatory diseases. Establishment of immune markers and methods in evaluating the effects of antigen-specific cellular and humoral immune responses will help the application of oral tolerance in the treatment of human diseases. The present article observed the effects of chicken collagen II […]

Oral administration of type II collagen suppresses pro‐inflammatory mediator production by synoviocytes in rats with adjuvant arthritis

The objective of this study was to investigate the effect of the oral administration of type II collagen (CII) on pro‐inflammatory mediator production by synoviocytes in rats with adjuvant arthritis (AA). Sprague‐Dawley rats were fed with bovine CII either before immunization with Complete Freund’s adjuvant (CFA) or after initiation of arthritis. Hind paw secondary swelling […]

Type II collagen degradation and its regulation in articular cartilage in osteoarthritis

INTRO: The progressive degeneration of articular cartilage is an underlying problem in the pathogenesis of osteoarthritis(OA) as well as in rheumatoid arthritis (RA) and other inflammation arthritides. It leads to a loss of joint function, frequently accompanied by debilitating pain. In idiopathic OA this is a degenerative process that may cover a period of 20–30 years, […]